Beyond Standard Health Panels: The Biomarkers That Truly Matter
Health Decoded
Unlock your full human potential with the Health Decoded podcast as hosts Dr. Alessi and Matt Tack break down the truth about all things health and empower you to take charge of your well-being.
Dr. Alfred AlessiMatt Tack

Beyond Standard Health Panels: The Biomarkers That Truly Matter

S4 E74 • Jul 28, 2026 • 24 mins

In this episode, Dr. Alfred Alessi and Matt Tack discuss the limitations of standard health panels, focusing on disease detection vs. performance measurement. They explore five overlooked biomarker categories, starting with lipid panels and particle count. They cover APOB for cardiovascular risk, glucose and insulin resistance for energy levels, inflammation markers like HSCRP and homocysteine, and hormone panels focusing on free testosterone. The importance of body composition and DEXA scans is also highlighted. A case study shows actionable protocols from biomarker data, concluding with a summary of key biomarkers for a comprehensive physical evaluation.

Key Points

  • Standard physicals are designed to catch diseases, not to measure optimal performance or predict future health issues.
  • Advanced lipid markers like ApoB, fasting insulin, HOMA-IR, inflammation markers like HSCRP and homocysteine, a full hormone panel, and a DEXA scan provide a more comprehensive picture of one's health.
  • Functional medicine focuses on interpreting multiple interconnected biomarkers to create a coordinated protocol, rather than targeting each marker in isolation.
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